News Downloads About Us Contact Us
Paper Titles
Dynamics of Micro Algae in Relation to Water Quality Parameters of Pasupatheswarar Temple Pond, Annamalai Nagar, Tamil Nadu
p.1
Antimicrobial Activity of Crinum defixum Ker - Gawler Leaves
p.8
The Structure of Jhum (Traditional Shifting Cultivation System): Prospect or Threat to Climate
p.16
Anopheline Mosquitoes and the Malaria Scourge
p.31
Antibacterial Activity of Extracts of Leaves of Nerium indicum in Combination with Antibiotics
p.41
Effect of Pruning Intensities on the Performance of Fruit Plants under Mid-Hill Condition of Eastern Himalayas: Case Study on Guava
p.46
Isolation and Identification of Vibrio sp. in the Hepatopancreas of Cultured White Pacific Shrimp (Litopenaeus vannamei)
p.52
Trend Analysis of Flood Peaks in Lower Reaches of Satluj River, Himachal Pradesh, India
p.60
Identification of Critical Periods Environmentally Sensitive to Normal Performance of Vanaraja Poultry Breed in Climatically Different Locations
p.76

Antibacterial Activity of Extracts of Leaves of Nerium indicum in Combination with Antibiotics

Article Preview

Abstract:

Methanol and ethanol extract showed antibacterial activity in range of 0-11 at 10 mg/mL at against all tested bacterial species. Methanol extract with amoxicillin exhibited effective inhibition E. coli. This combination showed antagonistic effect against B. subtilis and S. aureus. Interaction of ethanol extract with amoxicillin also showed effective inhibition against E. coli and decreased activity against B. subtilis and S. aureus.Methanol extract did not show inhibition against P. aeruginosa but it enhanced activity of ciprofloxacin on combination. Ethanol extract also exhibited effective inhibition against P. aeruginosa on combination with ciprofloxacin. But antagonist effect was observed on interaction of both extract with ciprofloxacin against other bacterial species.Interaction of methanol and ceftazidime showed mostly decreased or indifferent effect against all bacterial species. Ethanol extract with ceftazidime resulted in higher inhibition against E. coli. Combination of methanol extract with erythromycin showed higher inhibition against E. coli and also very effective inhibition against S. aureus. This combination resulted in decreased activity against B. subtilis. Ethanol extract with erythromycin also showed synergistic effect against S. aureus and effective inhibition against E. coli. These results indicate that both methanol and ethanol extract has potential to enhance the combination effect with erythromycin against S. aureus and E. coli.

By email View Pdf

Info:

Periodical:

International Letters of Natural Sciences (Volume 46)

Pages:

41-45

DOI:

https://doi.org/10.56431/p-25wpx9

Citation:

Cite this paper

Online since:

September 2015

Authors:

Piyush Vyas, Arvind Suthar, Deepkumar Joshi

Keywords:

Antibacterial Activity, Antibiotic, Nerium indicum

Export:

RIS, BibTeX

Permissions:

Creative Commons CC BY 4.0

Share:

Citation:

References

[1] Samy, R. P., Ignacimuthu, S., & Raja, D. P. (1999). Preliminary screening of ethnomedicinal plants from India. Journal of Ethnopharmacology, 66(2), 235-240.

DOI: 10.1016/s0378-8741(99)00038-0

Google Scholar

[2] Abreu, A. C., McBain, A. J., & Simoes, M. (2012). Plants as sources of new antimicrobials and resistance-modifying agents. Natural product reports, 29(9), 1007-1021.

DOI: 10.1039/c2np20035j

Google Scholar

[3] Hemaiswarya, S., Kruthiventi, A. K., & Doble, M. (2008). Synergism between natural products and antibiotics against infectious diseases. Phytomedicine,15(8), 639-652.

DOI: 10.1016/j.phymed.2008.06.008

Google Scholar

[4] Chatterjee, S. K., Bhattacharjee, I., & Chandra, G. (2009). In vitro synergistic effect of doxycycline & ofloxacin in combination with ethanolic leaf extract of Vangueria spinosa against four pathogenic bacteria. Indian J Med Res, 130, 475-478.

Google Scholar

[5] Aiyegoro, O., Adewusi, A., Oyedemi, S., Akinpelu, D., & Okoh, A. (2011). Interactions of antibiotics and methanolic crude extracts of Afzelia Africana (Smith.) against drug resistance bacterial isolates. International journal of molecular sciences, 12(7), 4477-4487.

DOI: 10.3390/ijms12074477

Google Scholar

[6] Purushotham, K. G., Arun, P., Jayarani, J. J., Vasnthakumari, R., Sankar, L., & Reddy, B. R. (2010). Synergistic in vitro antibacterial activity of Tectona grandis leaves with tetracycline. Int J PharmTech Res, 2, 519-523.

Google Scholar

[7] Sharma, B., Fatima, A., & Agarwa, P.(2013). A Review: Phytochemistry and Pharmacological Potential of Nerium indicum Mill, 3(1), 39-45.

Google Scholar

[8] Jawarkar, A.G., Shrirao, A.V., Mohale, D.S., Chandewar , A.V., Marathe, S.J., & Mahajan, P.G. .(2012). Brief Review on Medicinal Potential of Nerium indicum, International Journal of Institutional Pharmacy and Life Sciences, 2(2), 521-527.

Google Scholar

[9] http://www.spicesmedicinalherbs.com/nerium-indicum.html

Google Scholar

[10] http://www.motherherbs.com/nerium-indicum.html

Google Scholar

[11] Reddy, B. U. (2010). Antimicrobial Activity of Thevetia Peruviana (Pers.) K. Schum. and Nerium Indicum Linn. Internet Journal of Pharmacology, 8(2), 2.

DOI: 10.5580/d37

Google Scholar

[12] Vinayagam, A., & Sudha, P. N. (2011). Antioxidant activity of methanolic extracts of leaves and flowers of Nerium indicum. Int. J. Pharm. Sci. Res, 2, 1548-1553.

Google Scholar

[13] Shah, A., Zambare, A. V., Desai, A., & Chakraborthy, G. S. BIOLOGICAL EVALUATIONS OF POTENTIAL HERB-NERIUM INDICUM (LINN.). International Journal of Pharmaceutical Sciences and Research, 2(2), 418-423

Google Scholar

[14] Rajbhandari, M., Wegner, U., Jülich, M., Schoepke, T., & Mentel, R. (2001). Screening of Nepalese medicinal plants for antiviral activity. Journal of Ethnopharmacology, 74(3), 251-255.

DOI: 10.1016/s0378-8741(00)00374-3

Google Scholar

[15] Sharma, B., Fatima, A., & Agarwa, P.(2013). A Review: Phytochemistry and Pharmacological Potential of Nerium indicum Mill,3(1),39-45.

Google Scholar

[16] http://www.mpbd.info/plants/nerium-indicum.php

Google Scholar

[17] Kaur, S. P., Rao, R., & Nanda, S. (2011). AMOXICILLIN: A BROAD SPECTRUM ANTIBIOTIC. International Journal of Pharmacy & Pharmaceutical Sciences, 3(3).

Google Scholar

[18] Adikwu, E., & Brambaifa, N. (2012). Ciprofloxacin Cardiotoxicity and Hepatotoxicity in Humans and Animals. Pharmacology & Pharmacy, 3(2).

DOI: 10.4236/pp.2012.32028

Google Scholar

[19] Gay, J. D., DeYoung, D. R., & Roberts, G. D. (1984). In vitro activities of norfloxacin and ciprofloxacin against Mycobacterium tuberculosis, M. avium complex, M. chelonei, M. fortuitum, and M. kansasii. Antimicrobial agents and chemotherapy, 26(1), 94-96.

DOI: 10.1128/aac.26.1.94

Google Scholar

[20] http://en.wikipedia.org/wiki/Erythromycin

Google Scholar

[21] Savoia, D. (2012). Plant-derived antimicrobial compounds: alternatives to antibiotics. Future microbiology, 7(8), 979-990.

DOI: 10.2217/fmb.12.68

Google Scholar

[22] Sibanda, T., & Okoh, A. I. (2007). The challenges of overcoming antibiotic resistance: Plant extracts as potential sources of antimicrobial and resistance modifying agents. African Journal of Biotechnology, 6(25), 2886-2896.

Google Scholar

[23] Stefanovic, O., & Comic, L. (2012). Synergistic antibacterial interaction between Melissa officinalis extracts and antibiotics. Journal of Applied Pharmaceutical Science, 02 (01), 01-05.

Google Scholar

© 2025 AOA Academic Open Access Ltd, Cyprus. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For open access content, terms of the Creative Commons licensing CC-BY are applied. AcademicOA.com is a registered trademark of AOA Academic Open Access Ltd, Cyprus.