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Modern Aspects on Shigella Pathogenecity and Vaccine Development - A Review

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Abstract:

Shigella species are intracytosolic Gram-negative invasive enteropathogenic bacteria, causing the rupture, invasion and inflammatory destruction of the human colonic epithelium. They utilize the host cytoskeletal components to form propulsive actin tails. The so-called invasive phenotype of Shigella is linked to expression of a type III secretory system (TTSS) injecting effector proteins into the epithelial cell membrane and cytoplasm, thereby inducing local but massive changes in the cell cytoskeleton that lead to bacterial internalization into non-phagocytic intestinal epithelial cells. The molecular and cellular bases of this invasive phenotype essentially encompass crossing of the epithelial lining, apoptotic killing of macrophages, entry into epithelial cells, and escape into the cytoplasm, followed by cell-to-cell spread. Intracellular colonization is likely to protect the micro-organisms from killing by humoral and cellular effectors of the innate immune response. Concurrently, the capacity of Shigella to reprogram invaded epithelial cells to produce proinflammatory mediators plays a major role in the strong inflammatory profile of the disease. This profile is likely to impact on the nature and quality of the adaptive response, which is dominated by humoral protection at the mucosal level. In recent years, a large amount of information has been generated regarding the host, pathogen and environmental factors that impact the pathogenesis of shigellosis at the cellular and molecular level. This review summarizes what is currently known about Shigella, detailing those factors that contribute to pathogenesis and examining the current progress in the development of a vaccine

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Periodical:

International Letters of Natural Sciences (Volume 17)

Pages:

12-20

DOI:

https://doi.org/10.56431/p-6zg77o

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Cite this paper

Online since:

June 2014

Authors:

Partha Pal*

Keywords:

Enteropathogen, Pathogenesis, Shigella, TTS-System, Vaccine

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Creative Commons CC BY 4.0

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* - Corresponding Author

References

[1] Alto N.M., Shao F., Lazar C.S., Brost R.L., Chua G., Matto S., McMahon S.A., Ghosh P., Hughes T.R., Boone C., Dixon J.E., Cell 124 (2006) 133-145.

DOI: 10.1016/j.cell.2005.10.031

Google Scholar

[2] Ashkenazi S., Passwell J.H, Harlev E., Miron D., Dagan R., Ramon R., Farzam N., Majadly F., Bryla D.A., Karpas A.B., Robbins J.B., Schneerson R., J Infect Dis 179 (1999) 1565-1568.

DOI: 10.1086/314759

Google Scholar

[3] Barnoy S., Baqar S., Kaminski R.W., Collins T., Nemelka K., Hale T.L., Ranallo R.T., Venkatesan M.M., Vaccine 29 (2011) 6371-6378.

DOI: 10.1016/j.vaccine.2011.04.115

Google Scholar

[4] Bedford L., Fonseka S., Boren T., Ranallo R.T, Suvarnapunya A.E, Lee J.E., Barnoy S., venkatesan M.M., Gut Microbes 2 (2011) 244-251.

DOI: 10.4161/gmic.2.4.17042

Google Scholar

[5] Bompard G., Caron E., J Cell Biol 166 (2004) 957-962.

Google Scholar

[6] Buchrieser C., Glaser P., Rusniok C., Nedjari H., D'Hauteville H., Kunst F., Sansonetti P., Parsot C., Mol Microbiol 38 (2000) 760-771.

DOI: 10.1046/j.1365-2958.2000.02179.x

Google Scholar

[7] Clerc P., Sansonetti P.J., Infect Immun. 55 (1987) 2681-2688.

Google Scholar

[8] Cohen D., Green M., Block C., Slepon R., Ofek I., J Clin Microbiol 29 (1991) 386-389.

Google Scholar

[9] Costa S.C., Schmitz A.M., Jahufar F.F., Boyd J.D., Cho M.Y., Glicksman M.A., Lesser C.F., M Bio 3 (2012) e00243-00211.

Google Scholar

[10] DuPont H.L., Levine M.M., Hornick R.B., Formal S.B., J Infect Dis 159 (1989) 1126-1128.

Google Scholar

[11] Egile C., Loisel T.P., Laurent V. Li R., Pantaloni D., Sansonetti P.J., Carlier M.F., J Cell Biol 146 (1999) 1319-1332.

DOI: 10.1083/jcb.146.6.1319

Google Scholar

[12] Ewing W.H., J Bacteriol 57 (1949) 633-638.

Google Scholar

[13] Fukushima M., Kakinuma K., Kawaguchi R., J Clin Microbiol 40 (2002) 2779-2785.

Google Scholar

[14] George D.T., Mathesius U., Behm C.A., Verma N.K., PLoS ONE 9(4) (2014) e94954.

Google Scholar

[15] Goldberg M.B., Microbiol Mol Biol Rev 65 (2001) 595-626.

Google Scholar

[16] Hachani A., Biskri L., Rossi G., Marty A., Menard R., Sansonetti P.J., Parsot C., Van Nhieu G.T., Bernardini M.L., Allaoui A., Microbes Infect 10 (2008) 260-268.

DOI: 10.1016/j.micinf.2007.11.011

Google Scholar

[17] Handa Y., Suzuki M., Ohya K., Iwai H., Ishijima N., Koleske A.J., Fukui Y., Sasakawa C., Nat Cell Biol 9 (2007) 121-128.

DOI: 10.1038/ncb1526

Google Scholar

[18] Heine S.J., Diaz-McNair J., Martinez-Becerra F.J., Choudhari S.P., Clements J.D., Picking W.L., Pasetti M.F., Vaccine 31 (2013) 2919-2929.

DOI: 10.1016/j.vaccine.2013.04.045

Google Scholar

[19] Ho H.Y., Rohatgi R., Lebensohn A.M., Le Ma., Li J., Gygi S.P., Kirschner M.W., Cell 118 (2004) 203-216.

DOI: 10.1016/j.cell.2004.06.027

Google Scholar

[20] Huang Z., Sutton S.E., Wallenfang A.J., Orchard R.C., Wu X., Feng Y., Chai J., Alto N.M., Nat Struct Mol Biol 16 (2009) 853-860.

DOI: 10.1038/nsmb.1647

Google Scholar

[21] Islam D., Bandholtz L., Nilsson J., Wigzell H., Christensson B., Agerberth B., Gudmundsson G., Nat Med 7 (2001) 180-185.

DOI: 10.1038/84627

Google Scholar

[22] Jiang Y. et al., Plasmid 54 (2005) 149-159.

Google Scholar

[23] Jin Q. et al., Nucleic Acids Res 30 (2002) 4432-4441.

Google Scholar

[24] Kotloff K.L., Winikoff J.P., Ivanoff B., Clemens J.D., Swerdlow D.L., Sansonetti P.J., Adak G.K., Levine M.M., Bull WHO 77 (1999) 651-666.

Google Scholar

[25] Lan R., Alles M.C., Donohoe K., Martinez M.B., Reeves P.R., Infect Immun. 72 (2004) 5080-5088.

Google Scholar

[26] Lan R., Reeves P.R., Microbes Infect 4 (2002) 1125-1132.

Google Scholar

[27] Levine M.M., Kotloff K.L., Barry E.M., Pasetti M.F., Sztein M.B, Nat Rev Microbiol 5 (2007) 540-553.

Google Scholar

[28] Leung Y., Ally S., Goldberg M.B., Cell Host Microbe 3 (2008) 39-47.

Google Scholar

[29] Lommel S., Benesch S., Rottner K., Franz T., Wehland J., Kuhn R., EMBO Rep 2 (2001) 850-857.

Google Scholar

[30] Martinez-Becerra F.J. et al., Infect Immun 80 (2012) 1222-1231.

Google Scholar

[31] Martinez-Becerra F.J., Scobey M., Harrison K., Choudhari S.P., Quick A.M., Joshi S.B., Middauqh C.R., Picking W.L., Vaccine 31 (2013) 2667-2672.

DOI: 10.1016/j.vaccine.2013.04.012

Google Scholar

[32] Meitert T., Pencu E., Ciudin L., Tonciu M., Arch Roum Pathol Exp Microbiol 43 (1984) 251-278.

Google Scholar

[33] Mel D.M., Arsic B.L., Radovanovic M.L., Litvinjenko S.A., Acta Microbiol Acad Sci Hung 21 (1974) 109-114.

Google Scholar

[34] Mel D., Gangarosa E.J., Radovanovic M.L., Arsic B.L., Litvinjenko S., Bull World Health Org 45 (1971) 457-464.

Google Scholar

[35] Menard R., Sansonetti P., Parsot C., EMBO J 13 (1994) 5293-5302.

Google Scholar

[36] Nie H. et al., BMC Genomics 7 (2006) 173.

Google Scholar

[37] Niebuhr K., Jouihri N., Allaoui A., Gounon P., Sansonetti P.J., Parsot C., Mol Microbiol 38 (2000) 8-19.

Google Scholar

[38] Ochman H., Whittam T., Caugant D.A., Selander R.K., J Gen Microbiol 129 (1983) 2715-2726.

Google Scholar

[39] Ohya K., Handa Y., Ogawa M., Suzuki M., Sasakawa C., J Biol Chem 280 (2005) 24022-24034.

DOI: 10.1074/jbc.m502509200

Google Scholar

[40] Ogawa M., Sasakawa C., Cell Microbiol 8 (2006) 177-184.

Google Scholar

[41] Ogawa M., Susuki T., Tatsuno I., Abe H., Sasakawa C., Mol Microbiol 48 (2003) 913-931.

Google Scholar

[42] Page A.L., Sansonetti P., Parsot C., Mol Microbiol 43 (2002) 1533-1542.

Google Scholar

[43] Parsot C., FEMS Microbiol Lett 252 (2005) 11-18.

Google Scholar

[44] Passwell J.H., Ashkenazi S., Banet-Levi Y., Ramon R., Farzan N., Lerner-Geva L., Vaccine 28 (2010) 231-235.

Google Scholar

[45] Passwell J.H. et al., Pediatr Infect Dis J 22 (2003) 701-706.

Google Scholar

[46] Passwell J.H., Freier S., Shor R., Farzan N., Block C., Lison M., Shiff E., Ashkenazi S., Pediatr Infect Dis J 14 (1995) 859-865.

DOI: 10.1097/00006454-199510000-00008

Google Scholar

[47] Peng J., Zhang X., Yang J., Wang J., Yang E., Bin W., Wei C., Sun M., Jin Q., BMC Genomics 7 (2006) 218.

Google Scholar

[48] Pupo G.M., Karaolis D.K., Lan R., Reeves P.R., Infect Immun 65 (1997) 2685-2692.

Google Scholar

[49] Pupo G.M., Lan R., Reeves P.R., Proc Natl Acad Sci USA 97 (2000) 10567-10572.

Google Scholar

[50] Ranallo R.T., Fonseka S., Boren T.L., Bedford L.A., Kaminski R.W., Thakkar S., Venkatesan M.M., Vaccine 30 (2012) 5159-5171.

DOI: 10.1016/j.vaccine.2012.05.003

Google Scholar

[51] Rolland K., Lambert-Zechovsky N., Picard B., Denamur E., Microbiology 144 (1998) 2667-2672.

DOI: 10.1099/00221287-144-9-2667

Google Scholar

[52] Sansonetti P.J., PloS Med 3 (2006) e354.

Google Scholar

[53] Sansonetti P.J., Hale T.L., Dammin G.J., Kapfer C., Collins H.H., Formal S.B., Infect Immun 39 (1983) 1392-1402.

DOI: 10.1128/iai.39.3.1392-1402.1983

Google Scholar

[54] Sansonetti P.J., Kopecko D.J., Formal S.B., Infect Immun. 35 (1982) 852-860.

Google Scholar

[55] Sasakawa C., Kamata K., Sakai T., Murayama S.Y., Makino S., Yoshikawa M., Infect Immun 54 (1986) 470-475.

Google Scholar

[56] Schmitz A.M., Morrison M., Agunwamba A.O., Nibert M.L., Lesser C.F., Nat Methods 6 (2009) 500-502.

Google Scholar

[57] Shepherd J., Wang G.L., Reeves P.R., Infect Immun. 68 (2000) 6056-6061.

Google Scholar

[58] Shiga K., Saikingaku Zasshi 25 (1897) 790-810.

Google Scholar

[59] Snaper S.B. et al., Nat Cell Biol 3 (2001) 897-904.

Google Scholar

[60] Suzuki T., Miki H., Takenawa T., Sasakawa C., EMBO J 17 (1998) 2767-2776.

Google Scholar

[61] Tran Van Nhieu G., Enninga J., Sansonetti P., Grompone G., Curr Opin Microbiol 8 (2005) 16-20.

Google Scholar

[62] Venkatesan M.M., Fernandez-Prada C., Buysse J.M., Formal S.B., Hale T.L., Vaccine 9 (1991) 358-363.

DOI: 10.1016/0264-410x(91)90064-d

Google Scholar

[63] Venkatesan M.M., Goldberg M.B., Rose D.J., Grotbeck E.J., Burland V., Blattner F.R., Infect Immun 69 (2001) 3271-3285.

DOI: 10.1128/iai.69.5.3271-3285.2001

Google Scholar

[64] Wei J. et al., Infect Immun. 71 (2003) 2775-2786.

Google Scholar

[65] WHO (2006) Geneva, Switzerland http://www.who.int/topics/global_burden_of_disease/en/

Google Scholar

[66] Yang F. et al., Nucleic Acids Res 33 (2005) 6445-6458.

Google Scholar

[67] Yang J., Nie H., Chen L., Zhang X., Yang F., Xu X., Zhu Y., Yu J., Jin Q., J Mol Evol 64 (2007) 71-79. ( Received 26 May 2014; accepted 02 June 2014 )

Google Scholar

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