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HomeInternational Letters of Natural SciencesInternational Letters of Natural Sciences Vol. 45Neuroprotective Strategies Using Vegetal Compounds...

Neuroprotective Strategies Using Vegetal Compounds in the Treatment of Alzheimer’s Disease

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Abstract:

Lately, different therapy strategies for treating or slowing the progression of Alzheimer's disease are being analyzed. Moreover, the last two decades have seen a considerable research effort directed towards discovering the causes of Alzheimer's disease with the ultimate hope of developing safe and effective pharmacological treatments. In addition to the therapeutic strategies based on targeted drugs, the regimens will require the simultaneous application of neuroprotective drugs. Therefore, although there is currently no "cure" for Alzheimer's disease, a large number of potential therapeutic strategies emerged lately. In this small mini-review we will selectively describe some of the compounds derived from plants that could have a great potential in the treatment of various diseases, including Alzheimer's disease. In this way, there are many plant species that have been traditionally used for memory disorders. The differentiated results and powerful activity of these extracts are making these neuroprotective strategies to be somehow plausible for the treatment of Alzheimer's disease. In addition, these plants can be examined in order to isolate and identify their active ingredients and this can serve as a starting point to find safer and more effective agents for therapeutic use. On thing is certain: as the effective treatment options are limited, there is a demand for new drugs. Thus, plant extracts or vegetal compounds could represent an important part in this equation.

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International Letters of Natural Sciences (Volume 45)

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56-62

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https://doi.org/10.56431/p-fgii5v

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Online since:

August 2015

Authors:

Loredana Sandu, Alin Ciobica, Radu Lefter, Daniel Timofte*, Emil Anton

Keywords:

Alzheimer's Disease, Antioxidants, Neuroprotective Vegetal Compounds

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* - Corresponding Author

[1] R. Webster, Neurotransmitters, Drugs and Brain Function, John Wiley & Sons, London, 2005, 5-67.

[2] H. Kaplan, B. Sadock, Synopsis of Psychiatry, 7th Edition, William & Wilkins, Maryland, 1994.

[3] M. Padurariu, A. Ciobica, R. Lefter, I. Serban, C. Stefanescu, R. Chirita, The oxidative stress hypothesis in Alzheimer's disease, Psychiatr Danub. 25 (2013) 401-9.

[4] S. Gauthier, M. Emre, M. Farlow, R. Bullock, G. Grossberg S. Potkin, Strategies for continued successful treatment of Alzheimer's disease: switching cholinesterase inhibitors, Curr Med Res Opin. 19 (2003) 707–714.

DOI: 10.1185/030079903125002450

[5] Z. Ji, T. Dong, W. Ye, R. Choi, C. Lo, K. Tsim, Ginsenoside Re attenuate β-amyloid and serum-free induced neurotoxicity in PC12 cells, J Ethnopharmacol. 107 (2006) 48–52.

DOI: 10.1016/j.jep.2006.02.004

[6] M. Findeis, Approaches to discovery and characterization of inhibitors of amyloid-beta peptide polymerization, Biochim Biophys Acta. 1502 (2000) 76–84.

DOI: 10.1016/s0925-4439(00)00034-x

[7] M. Padurariu, A. Ciobica, I. Mavroudis, D. Fotiou, S. Baloyannis, Hippocampal neuronal loss in the CA1 and CA3 areas of Alzheimer's disease patients, Psychiatr Danub. 24 (2012) 152-8.

[8] S. Scheff, D. Price, F. Schmitt, M. Scheff, E. Mufson, Synaptic loss in the inferior temporal gyrus in mild cognitive impairment and Alzheimer's disease, J Alzheimers Dis. 24 (2011) 547-57.

DOI: 10.3233/jad-2011-101782

[9] R. Pinder, Is Alzheimer's a Preventable Disease?, Annals of General Psychiatry. 7 (2008) 1.

[10] I. Serban, C.Toarba, S. Hogas, A. Covic, A. Ciobica, R. Chirita, M. Graur, The relevance of body mass index in the cognitive status of diabetic patients with different alcohol drinking patterns, Arch. Biol. Sci. 66 (2014) 347-353.

DOI: 10.2298/abs1401347t

[11] A. Basli, S. Soulet, N. Chaher, J. Mérillon, M. Chibane, J. Monti, T. Richard, Winepolyphenols: potential agents in neuroprotection, Oxid Med Cell Longev. 2012 (2012) 805762.

DOI: 10.1155/2012/805762

[12] J. Coyle, P. Kershaw, Galantamine a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer's disease, Biol Psychiatry. 49 (2001) 289–299.

DOI: 10.1016/s0006-3223(00)01101-x

[13] M. Mehta, A. Adem, M. Sabbagh, New acetylcholinesterase inhibitors for Alzheimer's disease, IJAD. 2012 (2012) 928-983.

[14] I. Kang, Y. Jeon, X. Yin, J. Nam, S. You, M. Hong et al., Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid and reduces beta-amyloid mediated neuronal death, Food Chem Toxicol. 49 (2011) 2252–2259.

DOI: 10.1016/j.fct.2011.06.023

[15] M. Yu, A. Wong, K. So, J. Fang, W. Yuen, R. Chang, New polysaccharide from Nerium indicum protects neurons via stress kinase signaling pathway. Brain Res. 1153 (2007) 221–230.

DOI: 10.1016/j.brainres.2007.03.074

[16] N. Gericke, Plants, products and people: Southern African perspectives. Advances in Phytomedicine, Elsevier, Amsterdam, 2002, 155–162.

DOI: 10.1016/s1572-557x(02)80022-8

[17] E. Adewusi, N. Moodley, V. Steenkamp, In vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from southern Africa. Asian Pac J Trop Med. 4 (2011) 829-835.

DOI: 10.1016/s1995-7645(11)60203-4

[18] R. Cao, W. Peng, Z. Wang, A. Xu, Beta-Carboline alkaloids: biochemical and pharmacological functions, Curr Med Chem. 14 (2007) 479–500.

DOI: 10.2174/092986707779940998

[19] M. Padurariu, A. Ciobica, L. Hritcu, B. Stoica, W. Bild, C. Stefanescu, Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease, Neurosci Lett. 469 (2010) 6-10.

DOI: 10.1016/j.neulet.2009.11.033

[20] L. Hritcu, V. Bild, H. Foyet, A. Ciobica, I. Serban, D. Timofte, E. Anton, Antioxidative effects of the methanolic extract of Hibiscus asper leaves in mice, Romanian Biotechnological Letters. 19 (2014) 9376-9383.

[21] M. Sano, S. Salloway, Moving from treatment to prevention in Alzheimer's disease with vitamin E and estrogen, Psychiatric Times, 1999.

[22] E. Abner, F. Schmitt, M. Mendiondo, J. Marcum, R. Kryscio, Vitamin E and all-cause mortality: a meta-analysis, Curr Aging Sci. 4 (2011) 158-70.

DOI: 10.2174/1874609811104020158

[23] E. Miller, R. Pastor-Barriuso, D. Dalal, R. Riemersma, L. Appel, E. Guallar, Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality, Ann Intern Med. 142 (2005) 37-46.

DOI: 10.7326/0003-4819-142-1-200501040-00110

[24] B. Drever, W. Anderson, G. Riedel, D. Kim, J. Ryu, D. Choi, B. Platt, The seed extract of Cassia obtusifolia offers neuroprotection to mouse hippocampal cultures. J Pharmacol Sci. 107 (2008) 380–392.

DOI: 10.1254/jphs.08034fp

[25] M. Golechha, J. Bhatia, D. Arya, Studies on effects of Emblica officinalis (Amla) on oxidative stress and cholinergic function in scopolamine induced amnesia in mice, J Environ Biol. 33 (2012) 95–100.

[26] K. Selvendiran, J. Singh, K. Krishnan, D. Sakthisekaran, Cytoprotective effect of piperine against benzo[a]pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice, Fitoterapia. 74 (2003); 109–115.

DOI: 10.1016/s0367-326x(02)00304-0

[27] K. Srinivasan, Black pepper and its pungent principle-piperine: a review of diverse physiological effects, Crit Rev Food Sci. 47 (2007) 735–748.

DOI: 10.1080/10408390601062054

[28] M. Azzubaidi, A. Saxena, N. Talib, Q. Ahmed, B. Dogarai, Protective effect of treatment with black cumin oil on spatial cognitive functions of rats that suffered global cerebrovascular hypoperfusion, Acta Neurobiol Exp (Wars). 72 (2012) 154–165.

[29] T. Dillinger, P. Barriga, S. Escárcega, M. Jimenez, D. Salazar Lowe et al., Food of the gods: cure for humanity? A cultural history of the medicinal and ritual use of chocolate, J Nutr. 130 (2000) 2057S–2072S.

DOI: 10.1093/jn/130.8.2057s

[30] M. Galleano, P. Oteiza, C. Fraga, Cocoa, chocolate, and cardiovascular disease, J Cardiovasc Pharmacol. 54 (2009) 483–490.

DOI: 10.1097/fjc.0b013e3181b76787

[31] A. Nehlig, The neuroprotective effects of cocoa flavanol and its influence on cognitive performance, Br J Clin Pharmacol. 75 (2013) 716-727.

DOI: 10.1111/j.1365-2125.2012.04378.x

[32] K. Rahman, Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging. 22 (2007) 219–236.

[33] B. Zhao, X. Li, R. He, S. Cheng, W. Xin, Scavenging effect of extracts of green tea and natural antioxidants on active oxygen radicals, Cell Biophys. 14 (1989) 175–185.

DOI: 10.1007/bf02797132

[34] M. Singh, M. Arseneaul, T. Sanderson, V. Murthy, C, Ramassamy, Challenges for research on polyphenols from foods in Alzheimer's disease: Bioavailability, metabolism, and cellular and molecular mechanisms, J Agric Food Chem. 56 (2008) 4855–4873.

DOI: 10.1021/jf0735073

[35] D. Katz, K. Doughty, A. Ali, Cocoa and chocolate in human health and disease, Antioxid Redox Signal. 15 (2011) 2779–2811.

DOI: 10.1089/ars.2010.3697

[36] D. Kim, J. Kim, Y. Han, Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult, J Altern Complement Med. 13 (2007) 333–340.

DOI: 10.1089/acm.2006.6107

[37] J. Dugoua, D. Seely, D. Perri, K. Cooley, T. Forelli et al., From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark, Can J Physiol Pharmacol. 85 (2007) 837–847.

DOI: 10.1139/y07-080

[38] A. Khan, M. Safdar, M. Ali Khan, K. Khattak, R. Anderson, Cinnamon improves glucose and lipids of people with type 2 diabetes, Diabetes Care. 26 (2003) 3215–3218.

DOI: 10.2337/diacare.26.12.3215

[39] S. Brahmachari, A. Jana, K. Pahan, Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses, J Immunol. 183 (2009) 5917–5927.

DOI: 10.4049/jimmunol.0803336

[40] B. Ouattara, R. Simard, R. Holley, G. Piette, A. Begin, Antibacterial activity of selected fatty acids and essential oils against six meat spoilage organisms, Int J Food Microbiol. 37 (1997) 155–162.

DOI: 10.1016/s0168-1605(97)00070-6

[41] D. Peterson, R. George, F. Scaramozzino, N. LaPointe, R. Anderson et al., Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro, J Alzheimers Dis. 17 (2009) 585–597.

DOI: 10.3233/jad-2009-1083

[42] R. Anderson, C. Broadhurst, M. Polansky, W. Schmidt, A. Khan et al, Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity, J Agric Food Chem. 52 (2004) 65–70.

DOI: 10.1021/jf034916b

[43] S. Bastianetto, S. Krantic, R. Quirion, Polyphenols as potential inhibitors of amyloid aggregation and toxicity: possible significance to Alzheimer's disease, Mini Rev Med Chem. 8 (2008) 429–435.

DOI: 10.2174/138955708784223512