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Virtual Screening and Docking Studies of Identified Potential Drug Target: Polysaccharide Deacetylase in Bacillus anthracis

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Abstract:

In recent years, insilico approaches have been predicting novel drug targets. The present day development in pharmaceutics mainly ponders on target based drugs and this has been aided by structure based drug designing and subtractive genomics. In the present study, the computational genome subtraction methodology was applied for identification of novel, potential drug target against Bacillus anthracis, cause of deadly anthrax. The potential drug target identified through subtractive genomics approach was considered as polysaccharide deacetylase. By virtual screening against NCI database and Drugbank chemical libraries, two potential lead molecules were predicted. Further the potential lead molecules and target protein were subjected for docking studies using Autodock.

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Periodical:

International Letters of Natural Sciences (Volume 34)

Pages:

70-77

DOI:

https://doi.org/10.56431/p-0e0nz6

Citation:

Cite this paper

Online since:

February 2015

Authors:

K. Zaveri*, A. Krishna Chaitanya, I. Bhaskar Reddy

Keywords:

Anthrax, Bacillus anthracis, Molecular Docking, Virtual Screenin

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RIS, BibTeX

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Creative Commons CC BY 4.0

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* - Corresponding Author

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