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Evaluation of Ursolic Acid as the Main Component Isolated from Catharanthus roseus against Hyperglycemia

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Abstract:

Ursolic acid with large amount (0.67% of dried plant weight) along with 7 compounds, namely as spatozoate (1), kaurenoic acid (2), ursonic acid (3), 3-hydroxy-11-ursen-28,13-olide (4), ursolic acid (5), vindoline (6) and mixture of β-sitosterol and stigmasterol were isolated from dichloromethane and ethyl acetate extracts which have shown anti-glucosidase activity of the whole plant of C.roseus. Some isolated compounds and their derivatives were also tested for anti-glucosidase and cytotoxicity.Ursolic acid was examined for hypoglycemic activity in alloxan-induced diabetic mice with dose of 200 and 300 mg/kg/day, respectively. The results have shown that the blood glucose level were reduced by 45.75% and 51.31% to compare with the control group. This study has confirmed that the main component of Vietnamese C. roseus has had significant anti-hyperglycemia activity.

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Periodical:

International Letters of Natural Sciences (Volume 50)

Pages:

7-17

DOI:

https://doi.org/10.56431/p-c398qk

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Online since:

January 2016

Authors:

Nguyen Thanh Tam, Dao Duc Thien, Tran Van Sung, Nguyen Thi Hoang Anh, Trinh Thi Thuy, Khuat Huu Trung, Tran Dang Xuan, Tran Dang Khanh

Keywords:

Anti-Glucosidase, Anti-Hyperglycemia, Catharanthus roseus, Diabetic

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Creative Commons CC BY 4.0

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